Bupropion treats depression and aids in quitting smoking. Bupropion also prevents depression caused by seasonal affective disorder (SAD).
Bupropion is an antidepressant that produces its primary effects through the inhibition of the re-uptake of Dopamine, Serotonin and Norepinephrine. It is particularly noted for improving the impaired concentration and diminished energy that many patients suffering from depression experience.
Bupropion does not cause the noted sexual dysfunction commonly associated with most antidepressant medications… making it a good choice for younger patients who are trying to have children or concerned about sexual side effects.
An important side effect of bupropion however is a decreased seizure threshold, which is more commonly seen with higher doses. This medication should therefore be avoided in patients with seizure disorders or conditions that predispose to seizures (concurrent alcohol abuse, benzodiazepine use, eating disorders etc…)
Individuals with anorexia nervosa or bulimia nervosa are especially prone to developing electrolyte abnormalities that can precipitate further into seizures. Therefore, a thorough history should be taken along with an appropriate physical exam.